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KMID : 0370220000440050399
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Yakhak Hoeji
2000 Volume.44 No. 5 p.399 ~ p.405
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Selective Cytotoxicity of Pt (Ⅱ) Complex Containing 1,2-Bis(diphenylphosphino)ethane on Human Gastric Cancer Cell-Lines and Normal Kidney Cells
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Rho Young-Soo
Chang Sung-Goo
Jung Jee-Chang
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Abstract
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We have synthesized a novel platinum (II) coordination complex containing trans-l-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis (diphenylphosphino)ethane (DPPE) as a leaving , group. In addition, nitrate was added to improve the water-solubility. A new series of [Pt (trans-1-DACH) (DPPE)]. 2NO3 (PC) was evaluated for its cytotoxic activity on MKN-45 human gastric adenocarcinoma cells and normal primary cultured kidney cells. PC has demonstrated high levels of cytotoxicity against MKN-45/S, MKN-45/ADR and MKN-45/CDDP cells. The cytotoxicity of PC against rabbit proximal renal tubular cells, human renal cortical cells, and human renal cortical tissues, determined using the MTT assaying technique, the [3H]-thymidine uptake and the glucose consumption tests, was found to be quite less than those of cisplatin. Based on these results, this novel platinum (II) coordination complex appears to be better for improving antitumor activities with low nephrotoxicity and is a valuable lead in the development of new, clinically available anticancer chemotherapeutic agents.
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KEYWORD
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Selective cytotoxicity, platinum (Ⅱ) coordination complex, antitumor activity, nephrotoxicity
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